Cardinals vs. Bills Prediction: Buffalo Predicted to Win Following Latest Data Analysis for NFL Week 1 [2024] (2024)

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Cardinals vs. Bills Prediction: Buffalo Predicted to Win Following Latest Data Analysis for NFL Week 1 [2024] (1)

Written by Dave Garofolo, Content Producer

The Buffalo Bills and Arizona Cardinals will lock horns in Week 1 of the NFL season at Highmark Stadium on Sunday, starting at 1:00PM ET.

Based on updated simulations, Dimers' proven NFL model (see Dimers Pro for full access) projects the Bills as the most likely winner of the game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cardinals-Bills game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Bills with a win probability of 71%, while the Cardinals have 29%."

Cardinals vs. Bills Game-Day Updates and Essential Details

The NFL Week 1 game between the Bills and Cardinals at Highmark Stadium is scheduled to begin at 1:00PM ET.

Dimers.com's in-depth preview of this week's Cardinals vs. Bills matchup includes our prediction, picks and the latest betting odds.

Before making any Bills vs. Cardinals picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

Cardinals vs. Bills Predictions

Using powerful machine learning and data analysis, we have simulated the result of Sunday's NFL game between the Cardinals and Bills 10,000 times as part of our NFL predictions coverage.

Our independent predictive model gives the Bills a 71% chance of beating the Cardinals in Week 1 of the NFL season. Our predicted final score has the Bills winning 26-20.

According to our model, the Cardinals (+6.5) have a 57% chance of covering the spread, while the over/under total of 47 points has an equal 50-50 chance of hitting.

Cardinals vs. Bills Odds

We have sourced the best betting odds in America for this game, which are listed here:

Bet TypeCardinalsBills
Spread+6.5 (-108)-6.5 (-110)
Moneyline+240-295
Totalo47 (-110)u47 (-105)

All odds are correct at the time of publication and are subject to change.

Cardinals vs. Bills Picks

Our model's biggest edge in the Cardinals vs. Bills matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best NFL picks for every game throughout the season.

Unlimited access to our picks, including this one, is available via Dimers Pro.

Cardinals vs. Bills TD Scorers

Who will score an anytime touchdown in Cardinals vs. Bills?

According to our model, Buffalo's Josh Allen is most likely to score the first touchdown in Cardinals vs. Bills.

Our projections give Allen an 11.0% chance of scoring the first TD at Highmark Stadium, while the Bills QB is a 46.9% chance of scoring an anytime touchdown.

First Touchdown Scorer Predictions

Arizona Cardinals

PlayerFirst TD Probability
James Conner9.2%
Marvin Harrison6.8%
Trey McBride5.5%

Buffalo Bills

PlayerFirst TD Probability
Josh Allen11.0%
James Cook7.9%
Dalton Kincaid5.6%

Anytime Touchdown Scorer Predictions

Arizona Cardinals

PlayerAnytime TD Probability
James Conner41.0%
Marvin Harrison32.1%
Trey McBride25.8%

Buffalo Bills

PlayerAnytime TD Probability
Josh Allen46.9%
James Cook35.2%
Dalton Kincaid27.0%

Cardinals vs Bills Player Props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Cardinals and Bills. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Cardinals-Bills page now to access every player prop projection.

Cardinals vs. Bills Quarterbacks

Of the starting quarterbacks, the Cardinals' Kyler Murray is projected to throw for fewer yards than the Bills' Josh Allen.

Cardinals Rushing

James Conner, Kyler Murray and Trey Benson are projected to be the leading rushers for the Cardinals.

PlayerPosition
James ConnerRB
Kyler MurrayQB
Trey BensonRB

Bills Rushing

James Cook, Josh Allen and Ray Davis are expected to lead the Bills in rushing yards.

PlayerPosition
James CookRB
Josh AllenQB
Ray DavisRB

Cardinals Receiving

Trey McBride, Marvin Harrison, Greg Dortch, Michael Wilson and Chris Moore are projected to top the receiving yards for the Cardinals.

PlayerPosition
Trey McBrideTE
Marvin HarrisonWR
Greg DortchWR
Michael WilsonWR
Chris MooreWR

Bills Receiving

Dalton Kincaid, Khalil Shakir, Keon Coleman, Curtis Samuel and James Cook are projected to lead the Bills in receiving yards.

PlayerPosition
Dalton KincaidTE
Khalil ShakirWR
Keon ColemanWR
Curtis SamuelWR
James CookRB

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Conclusion

We predict the Bills, with a 71% win probability, will likely beat the Cardinals on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Bills insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on NFL

Keep up with the latest NFL news and our data-driven NFL best bets and NFL parlay picks throughout the season. Plus, our Super Bowl odds provide the latest predictions for the Super Bowl, AFC, NFC and each division.

Cardinals vs. Bills Prediction: Buffalo Predicted to Win Following Latest Data Analysis for NFL Week 1 [2024] (2024)

FAQs

Who is favored to win, bills or cardinals? ›

The Buffalo Bills are 6.5-point favorites heading into Sunday's Kickoff Weekend matchup against the Arizona Cardinals at Highmark Stadium. The game will air at 1:00 pm on CBS. Here's a list of additional notes for Sunday's season opener ...

How to watch Bills Cardinals game? ›

How to watch the Arizona Cardinals vs. Buffalo Bills NFL game today: Livestream options, more
  1. Watch NFL football on Paramount+
  2. Start streaming NFL on CBS for free.
  3. Start your Walmart+ free trial.
  4. Start streaming the NFL on Fubo.
  5. $77 per month at Hulu.
  6. Shop NFL gear at Fanatics.
  7. $70 at Amazon.
1 hour ago

How to watch Buffalo Bills? ›

Stream the Bills on Paramount+

Stream the Bills on CBS with Paramount Plus! Subscribers can watch their live local games across devices all season long.

What are the odds the Cardinals win the Super Bowl? ›

Cardinals Super Bowl Odds Insights

The Cardinals' Super Bowl odds (+10000) rank them 24th in the league, three spots better compared to our computer rankings, where they rank 27th. The Cardinals have a 1% chance of winning the Super Bowl, based on their current odds (+10000).

Are the Bills favored to win the Super Bowl? ›

The Bills' Super Bowl odds (+1600) rank them seventh-best in the NFL, three spots worse than our computer rankings, where they rank fourth-best. Based on their current odds (+1600), the Bills sport a 5.9% chance of winning the Super Bowl.

Can I watch the Cardinals game on ESPN Plus? ›

How to stream baseball on ESPN+ ESPN+ subscribers can access baseball games* all season long at no additional cost.

Where are Buffalo Bills? ›

The team plays its home games at Highmark Stadium in Orchard Park, New York. The Bills are the only NFL team to play their home games within the state of New York. Founded in 1959 as a charter member of the American Football League (AFL), they joined the NFL in 1970 following the AFL–NFL merger.

Is the NFL on Peacock free? ›

Peacock. NBC's streaming service will give you access to several games, including all upcoming Sunday night matchups. Expect to pay a $8 or $14 monthly charge.

Can you watch Buffalo Bills on Amazon Prime? ›

Which channels air Buffalo Bills games? To watch all Buffalo Bills games, you'll need CBS, ESPN, FOX, NBC, and Amazon Prime Video. You can also stream the CBS channel with Paramount+ and NBC with Peacock. This doesn't include out-of-market games, though.

Who is Favoured to win in the Super Bowl? ›

The Kansas City Chiefs (+500) are the favorite to win Super Bowl LIX based on betting markets, followed by: San Francisco 49ers (+600) Baltimore Ravens (+1000) Detroit Lions (+1200)

Who is the Cardinals biggest rival football? ›

The Cardinals' biggest rivals are the Los Angeles Rams, the Seattle Seahawks and the San Francisco 49ers. The Cardinals also have a rivalry with the Chicago Bears that dates back to 1920, as they are the only two teams that remain from the NFL's inception in 1920.

Are the Bills favored to beat the Patriots? ›

The Bills are favorites to defeat the Patriots, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023.

Who is favored in the Eagles Cardinals game? ›

The Philadelphia Eagles (11-4) are considered favorites (-11) according to the bookmakers ahead of their game versus the Arizona Cardinals (3-12) on December 31, 2023, starting at 1:00 PM ET, airing on FOX. The game has an over/under of 48.5 points.

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