Updated: | First published:
![Cardinals vs. Bills Prediction: Buffalo Predicted to Win Following Latest Data Analysis for NFL Week 1 [2024] (1)](https://i0.wp.com/imgix.cosmicjs.com/4662a7f0-883c-11ee-9ebe-eb22b0517bf0-9b9263ffda712573f90804f393669ebe.jpg?w=80&auto=format,compress "Cardinals vs. Bills Prediction: Buffalo Predicted to Win Following Latest Data Analysis for NFL Week 1 [2024] (1)")
Written by Dave Garofolo, Content Producer
The Buffalo Bills and Arizona Cardinals will lock horns in Week 1 of the NFL season at Highmark Stadium on Sunday, starting at 1:00PM ET.
Based on updated simulations, Dimers' proven NFL model (see Dimers Pro for full access) projects the Bills as the most likely winner of the game.
"Using the most recent data, our experts ran 10,000 simulations of Sunday's Cardinals-Bills game," said Dimers' Chief Content Officer, Nick Slade.
"After accounting for recent updates and other variables, our prediction shows the Bills with a win probability of 71%, while the Cardinals have 29%."
Cardinals vs. Bills Game-Day Updates and Essential Details
The NFL Week 1 game between the Bills and Cardinals at Highmark Stadium is scheduled to begin at 1:00PM ET.
- Who: Arizona Cardinals vs. Buffalo Bills
- Date: Sunday, September 8, 2024
- Time: 1:00PM ET/10:00AM PT
- Venue: Highmark Stadium
- Tickets: Get tickets for the game on Ticketmaster
- Merchandise: Buy Bills and Cardinals gear at Fanatics
- Live Stream: Watch this game on CBS via Hulu, FuboTV or Paramount+
Dimers.com's in-depth preview of this week's Cardinals vs. Bills matchup includes our prediction, picks and the latest betting odds.
Before making any Bills vs. Cardinals picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.
Cardinals vs. Bills Predictions
Using powerful machine learning and data analysis, we have simulated the result of Sunday's NFL game between the Cardinals and Bills 10,000 times as part of our NFL predictions coverage.
Our independent predictive model gives the Bills a 71% chance of beating the Cardinals in Week 1 of the NFL season. Our predicted final score has the Bills winning 26-20.
According to our model, the Cardinals (+6.5) have a 57% chance of covering the spread, while the over/under total of 47 points has an equal 50-50 chance of hitting.
Cardinals vs. Bills Odds
We have sourced the best betting odds in America for this game, which are listed here:
| Bet Type | Cardinals | Bills |
|---|---|---|
| Spread | +6.5 (-108) | -6.5 (-110) |
| Moneyline | +240 | -295 |
| Total | o47 (-110) | u47 (-105) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Bills Picks
Our model's biggest edge in the Cardinals vs. Bills matchup is on the over/under.
Our expert predictions, aligned with the current odds, reveal the best NFL picks for every game throughout the season.
Unlimited access to our picks, including this one, is available via Dimers Pro.
Cardinals vs. Bills TD Scorers
Who will score an anytime touchdown in Cardinals vs. Bills?
According to our model, Buffalo's Josh Allen is most likely to score the first touchdown in Cardinals vs. Bills.
Our projections give Allen an 11.0% chance of scoring the first TD at Highmark Stadium, while the Bills QB is a 46.9% chance of scoring an anytime touchdown.
First Touchdown Scorer Predictions
Arizona Cardinals
| Player | First TD Probability |
|---|---|
| James Conner | 9.2% |
| Marvin Harrison | 6.8% |
| Trey McBride | 5.5% |
Buffalo Bills
| Player | First TD Probability |
|---|---|
| Josh Allen | 11.0% |
| James Cook | 7.9% |
| Dalton Kincaid | 5.6% |
Anytime Touchdown Scorer Predictions
Arizona Cardinals
| Player | Anytime TD Probability |
|---|---|
| James Conner | 41.0% |
| Marvin Harrison | 32.1% |
| Trey McBride | 25.8% |
Buffalo Bills
| Player | Anytime TD Probability |
|---|---|
| Josh Allen | 46.9% |
| James Cook | 35.2% |
| Dalton Kincaid | 27.0% |
Cardinals vs Bills Player Props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Cardinals and Bills. For detailed projections, join Dimers Pro.
Already a Dimers Pro member? Head to our Cardinals-Bills page now to access every player prop projection.
Cardinals vs. Bills Quarterbacks
Of the starting quarterbacks, the Cardinals' Kyler Murray is projected to throw for fewer yards than the Bills' Josh Allen.
Cardinals Rushing
James Conner, Kyler Murray and Trey Benson are projected to be the leading rushers for the Cardinals.
| Player | Position |
|---|---|
| James Conner | RB |
| Kyler Murray | QB |
| Trey Benson | RB |
Bills Rushing
James Cook, Josh Allen and Ray Davis are expected to lead the Bills in rushing yards.
| Player | Position |
|---|---|
| James Cook | RB |
| Josh Allen | QB |
| Ray Davis | RB |
Cardinals Receiving
Trey McBride, Marvin Harrison, Greg Dortch, Michael Wilson and Chris Moore are projected to top the receiving yards for the Cardinals.
| Player | Position |
|---|---|
| Trey McBride | TE |
| Marvin Harrison | WR |
| Greg Dortch | WR |
| Michael Wilson | WR |
| Chris Moore | WR |
Bills Receiving
Dalton Kincaid, Khalil Shakir, Keon Coleman, Curtis Samuel and James Cook are projected to lead the Bills in receiving yards.
| Player | Position |
|---|---|
| Dalton Kincaid | TE |
| Khalil Shakir | WR |
| Keon Coleman | WR |
| Curtis Samuel | WR |
| James Cook | RB |
NFL Fantasy and Betting Promos
Make the most of Dimers' Cardinals vs. Bills predictions by exploring the two exciting offers below.
DraftKings Pick6
Sign up for DraftKings Pick6 today! Play $5 and get $50 in Pick6 Credits, plus one month of NFL RedZone access.
FanDuel Sportsbook
Get ready for NFL Week 1 by joining FanDuel Sportsbook! Bet $5 and get $200 in bonus bets, plus 3 weeks of NFL Sunday Ticket.
Conclusion
We predict the Bills, with a 71% win probability, will likely beat the Cardinals on Sunday.
AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Bills insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
More on NFL
Keep up with the latest NFL news and our data-driven NFL best bets and NFL parlay picks throughout the season. Plus, our Super Bowl odds provide the latest predictions for the Super Bowl, AFC, NFC and each division.
![Cardinals vs. Bills Prediction: Buffalo Predicted to Win Following Latest Data Analysis for NFL Week 1 [2024] (2024)](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR42mP8/h8AAvMB+NzmkbcAAAAASUVORK5CYII=)